Exosome & PDRN Hair Growth Serums: A step-by-step guide for healthier, fuller hair through scalp regeneration
Atlantis Hair is a next-generation scalp booster developed by HJ Corporations in Korea. There are other Korean hair booster products that can likely use this same procedure, but I prefer Atlantis.
It combines plant-derived exosomes, PDRN (polydeoxyribonucleotide), bioactive peptides, and enzymes designed to support scalp health and stimulate new hair growth.
According to the manufacturer, each vial contains high-purity HPDRN (10,000 ppm from Alaskan salmon), approximately 500 million exosomes per milliliter, and a complex of amino acids and growth factors that target thinning or weakened hair.
This type of product is often used by professionals and experienced home users seeking to improve scalp vitality and encourage regrowth in areas affected by shedding, thinning, or damage from inflammation or stress.
Safety and Preparation
Before starting any scalp-stimulation program:
- Make sure the scalp is healthy, clean, and free of irritation or infection.
- If you have an underlying medical condition or are taking immune-related medication, check with a licensed medical provider before proceeding.
- Always perform a patch test on a small area (behind the ear or at the hairline) 24-48 hours before full application.
- Use only sterile equipment and practice clean technique throughout the process.
Recommended Tools and Depth
Use a manual micro-stamping device suitable for scalp application. This type of tool delivers consistent depth and coverage while avoiding the hair-snagging issues that can happen with pens or rollers.
Most at-home stampers are re-usable, typically rated for about 10-12 sessions if properly cleaned and the needles remain sharp and straight.
After each use:
- Rinse immediately under warm running water to remove residual serum or debris.
- Soak for 10-15 minutes in 70 % isopropyl alcohol or a hospital-grade disinfectant.
- Air-dry completely before storing in a covered, clean container.
- Replace the stamper as soon as you notice dullness, bending, or corrosion of the needles.
Set the needle depth between 0.25 mm and 0.5 mm for topical absorption. This depth is sufficient to open micro-channels in the skin without causing bleeding or discomfort.
Step-by-Step Application
1. Cleanse and Sanitize
Wash the scalp with a gentle shampoo, rinse thoroughly, and pat dry.
Wipe the treatment area with 70% isopropyl alcohol or a mild antiseptic to remove oils and bacteria.
2. Prepare the Vial
Arrange all tools and materials on a clean, disinfected surface before beginning.
You’ll need your micro-stamper, a fine-tooth comb, and one Atlantis Hair vial.
- Remove the protective seal and metal ring from the vial and gently lift off the top cap.
- Decide how you’ll dispense it:
- You can draw the serum into a 3 mL or 5 mL sterile syringe (without a needle) for easy drop-by-drop control, or
- Add a squeeze-top vial adapter if you have one, or
- Pour the contents into a small sterile bowl or glass dish. This gives you easy access to the serum without the risk of spilling or contaminating the vial. You can use a pipette or your fingertips for application.
If you plan to treat only a small area, you can withdraw half the contents, re-cap the vial, and refrigerate the remainder for later use (within about 14 days).
3. Apply the Booster
Dispense Atlantis Hair drop-by-drop directly onto the scalp, working methodically in small sections rather than trying to cover everything at once.
- Use the tail end of a clean, fine-tooth comb to create a straight part through the thinning area.
- Apply the serum lightly along that part line and gently spread it with your fingertips or the comb tip so it coats the exposed scalp.
- Micro-stamp directly along the part, keeping the needle depth between 0.25 – 0.5 mm.
- Immediately after stamping, apply a second layer of Atlantis Hair to the treated area. Tap lightly to aid penetration through the newly opened micro-channels.
- Move the comb about one inch (2-3 cm) over to create the next part, and repeat: apply, stamp, move.
- Continue this pattern until you’ve covered the entire target zone (crown, top, or front hairline).
This technique ensures that the serum actually reaches the scalp, not just the hair, and that the stamping channels are evenly spaced for consistent absorption.
4. Complete the Vial
Because each vial contains about 5 mL, it’s normal to have some amount left over when you finish stamping (unless you are trying to cover your entire scalp). Simply return to the treated areas and rub the remaining serum into the scalp with clean fingertips, massaging gently for 1-2 minutes to help it absorb.
You can also apply to areas not stamped. Some ingredients will penetrate through follicles and skin pores, providing hydration and mild stimulation.
Once the serum has been fully absorbed, continue to the next step.
5. Soothe and Hydrate with the Moisture Mist
The Atlantis Hair kit includes a 15 mL Soothing Moisture Mist designed to calm and re-hydrate the scalp post-treatment.
Hold the bottle about 6-8 inches (15-20 cm) from the scalp and lightly mist the entire treated area so that it feels comfortably damp, but not dripping.
Gently pat with clean fingertips to distribute. The mist cools, soothes, and helps maintain moisture as the active ingredients settle.
If desired, the mist can also be used between sessions to relieve dryness or tightness, especially in the days following a treatment.
Post-Treatment Care
- Avoid washing or applying other products for at least 12 hours.
- Skip harsh treatments (dye, bleach, perm, high-heat styling) for 48 hours.
- If redness or sensitivity occurs, apply a soothing, fragrance-free scalp serum or aloe-based gel.
Treatment Frequency
Most protocols suggest one vial per session, every two weeks, for five to eight sessions as an initial series.
Afterward, reduce to once monthly maintenance depending on scalp response.
Hair growth follows multi-month cycles – visible improvement (thicker strands, reduced shedding, baby hairs) often appears gradually after several treatments.
Tips for Success
- Document progress with before-and-after photos in consistent lighting.
- Stay hydrated and maintain balanced nutrition (protein, iron, zinc, vitamin D).
- Use gentle, sulfate-free shampoo between sessions.
- Avoid aggressive brushing or scratching the scalp.
- Consistency matters more than intensity – gentle and regular treatments yield the best results.
When to Pause or Stop
Discontinue treatments and seek professional advice if you experience:
- Prolonged redness or irritation lasting more than two days
- Burning, swelling, or pain
- Signs of infection (oozing, pustules, scabbing)
- Sudden worsening of hair loss or patchy bald spots
FAQs
Q: The kit comes with 10 vials. At two-week intervals, that’s about six months of care. Do I need to keep doing maintenance long-term to keep the results?
A: Yes – ongoing maintenance helps preserve progress.
Hair growth operates on slow biological cycles, and scalp regeneration products like Atlantis Hair primarily improve follicle health and signaling, not genetics. After completing the initial series (about 5 – 8 sessions), most users move into a monthly or bi-monthly maintenance phase to keep follicles in an active growth environment. If you completely stop all stimulation, the follicles gradually revert toward their baseline condition over several months.
Maintenance doesn’t always require full-strength sessions – many users switch to lighter micro-stamping or topical use of leftover vials every 4 – 6 weeks, paired with scalp massage, red-light therapy, or mild growth tonics to sustain results.
Q: Can Atlantis Hair be combined with Minoxidil, PRP, or other hair-growth treatments?
A: Yes – Atlantis Hair plays well with most growth-supporting treatments.
Because it primarily acts through tissue repair and inflammation control, it can complement Minoxidil, PRP, or low-level laser therapy (LLLT).
Here’s a smart way to combine them:
- Use Atlantis Hair every 2 weeks with micro-stamping.
- Apply topical Minoxidil or Rogaine only on alternate days, not immediately after stamping sessions (wait 48 hours).
- If doing PRP, schedule Atlantis sessions 1 – 2 weeks apart to avoid overlap irritation.
- LLLT or red-light scalp therapy can be done several times per week and supports both.
This combination helps accelerate visible regrowth while maintaining a calm, balanced scalp environment.
Q: Is micro-stamping painful, and can it cause shedding?
A: When done correctly, it’s virtually painless, especially at the shallow depths (0.25 – 0.5 mm) used for scalp absorption.
You might feel mild prickling or warmth, but it should never bleed or sting.
Occasionally, users notice temporary shedding after the first 1-2 sessions. This is known as the shedding or reset phase, where older hairs fall out to make way for new, stronger growth. It’s short-lived (usually 1-3 weeks) and generally followed by visible improvement in density and texture.
Q: Can I use Atlantis Hair on my eyebrows or beard area?
A: Yes, but with caution.
The formula is safe for skin application, but the needle depth must be reduced to 0.2 – 0.25 mm for facial areas, and the amount used should be minimal – just a few drops per zone. Eyebrow and beard hair follicles differ from scalp follicles in size and cycle length, so progress may be slower.
Avoid overlapping with active acne, retinoid treatments, or irritated skin.
Q: If I’m not experiencing balding, but just want thicker, healthier hair, should I treat my whole scalp or just the top where I can reach easily?
A: For general scalp health and thicker hair – not active hair loss – there’s no need to microneedle the entire scalp in one session.
Focus on the top, crown, and frontal zones, since these are most responsive to circulation and follicle support. Over time, you can rotate sections so that every area receives occasional stimulation.
If there are parts of the scalp that are hard to reach or not being micro-needled, you can still apply a thin layer of the serum and massage it in with your fingertips. Even without needling, some ingredients will penetrate through follicles and skin pores, providing hydration and mild stimulation. This approach makes efficient use of the serum and keeps the scalp balanced, especially for users treating mainly for hair quality, shine, and density rather than regrowth.
In short: treat what’s easy and beneficial, rotate areas occasionally, and lightly massage the remaining serum over the rest – the entire scalp will still benefit.
Q: Are plant-based exosomes strong enough, or do I need human-derived ones for real results?
A: Plant-derived exosomes can still be biologically active, but they behave differently.
They primarily deliver antioxidants, anti-inflammatory enzymes, and hydration factors, rather than the complex protein and RNA signals found in human-cell exosomes (such as those from umbilical or platelet sources). For scalp care, plant exosomes still play a meaningful role: they calm inflammation, protect follicles from oxidative stress, and improve barrier recovery after microneedling – all of which indirectly support hair growth. However, they don’t “reprogram” cells to the same regenerative depth as human-derived exosomes can.
Think of it this way:
- Plant exosomes: nurture, protect, and soothe the scalp environment.
- Human-derived exosomes: instruct cells to behave younger and rebuild tissue.
Atlantis Hair is on the nurturing end of that spectrum, but because it combines PDRN, peptides, and exosomes, its overall performance sits well above typical cosmetic-grade scalp tonics.
Q: How similar or different are the results compared with Calecim’s Professional Hair System?
A: Both products share the same delivery method — they’re applied through micro-stamping to enhance absorption — but they differ in biological source and ingredient profile.
- Atlantis Hair: Combines plant-derived exosomes, salmon-based PDRN, peptides, and amino enzymes for scalp regeneration. It focuses on improving scalp circulation, calming inflammation, and supporting new hair growth through multi-pathway stimulation.
- Calecim Professional Hair System: Uses umbilical-derived conditioned media (from red deer stem cells) rich in growth factors and signaling proteins. It targets follicle rejuvenation on a molecular level, encouraging hair thickening and regrowth.
In short:
- Atlantis Hair emphasizes scalp recovery and cellular nourishment with broad regenerative support.
- Calecim Hair System delivers stronger direct growth signaling through human-like growth factors.
Both are excellent when used consistently; many users alternate them — Atlantis for hydration and scalp health, Calecim for active follicle stimulation — since their mechanisms complement each other beautifully.
Q: How can I really step this up to the most effective treatment plan?
A: If you’re ready to go beyond basic use, Atlantis Hair can anchor a powerful regenerative cycle when paired with advanced serums like Calecim Pro Serum and Young Goose Vampire Exosomes.
Each plays a distinct role:
- Atlantis Hair – the foundation. It hydrates, calms, and prepares the scalp and skin for absorption while delivering PDRN, peptides, and plant exosomes.
- Calecim Pro Serum – the recovery partner. It supplies human-like growth factors and conditioned media to strengthen, repair, and maintain the results between sessions.
- Vampire Exosomes – the accelerator. These platelet-derived exosomes deliver the strongest regeneration signal for collagen, elasticity, and follicle renewal.
The most effective approach alternates these phases:
- Week 1: Recovery phase – Atlantis Hair + Calecim Pro Serum
- Week 3: Regeneration phase – Atlantis Hair + Vampire Exosomes
- Repeat
This rotation keeps Atlantis Hair’s biweekly rhythm while alternating the type of regenerative stimulus: Calecim for recovery and Vampire Exosomes for deeper rebuilding.
It allows the scalp and skin to rest, remodel, and continue improving month after month without overstimulation. The result is a continuously optimized environment for follicle strength, smoother skin texture, faster recovery, and steadily compounding improvements in density, tone, and radiance.
Final Thoughts
Atlantis Hair represents a modern, regenerative approach to hair restoration merging exosome therapy with PDRN, peptides, and precision micro-stamping delivery. Used consistently and safely, it can complement other hair-growth strategies such as low-level laser therapy, nutritional optimization, or physician-directed topicals.
The Soothing Moisture Mist completes the protocol by calming and hydrating the scalp environment helping every treatment end on a restorative note.
Results take patience and repetition, but with each session, the scalp environment becomes stronger, calmer, and more receptive to healthy new growth.
This article reflects independent analysis and interpretation based on publicly available information and scientific literature. It is not affiliated with or endorsed by any of the brands or products mentioned.