When it comes to powerhouse biotherapeutics, Laennec stands out. Manufactured by Japan Bio Products Co., Ltd. (JBP) and originally approved in Japan, Laennec is a human-placenta extract formulated using proprietary extraction technologies. The placenta source is rigorously screened and processed, and the resulting formulation contains growth-factors, peptides, amino acids, nucleic acid fragments and other bioactive substances derived from the placenta.
In Japan, Laennec is an approved pharmaceutical drug indicated for improving hepatic function in chronic liver disease. It is also KFDA-approved and widely used across South Korea and other parts of Asia in aesthetic and regenerative medicine for skin rejuvenation, recovery, and overall wellness. However, in the United States, European Union, United Kingdom, Australia, and New Zealand, Laennec is not FDA-approved or formally registered, so it isn’t available through traditional medical channels. Most Western physicians are unfamiliar with it and therefore unable to provide guidance on its use—yet it remains a cornerstone in many advanced Asian aesthetic and anti-aging protocols.
Laennec appeals because it bridges “medical-grade biologic” + “aesthetic/regenerative lifestyle” — it’s rooted as a pharmaceutical and yet widely adopted in advanced aesthetic and cosmetic protocols. Its versatility makes it ideal for skin, tissue regeneration, wellness layering, and aesthetic recovery support.
How People Use It
Outside of its official medical indication, Laennec has become a quiet secret in regenerative circles and used far beyond liver support. In Japan and Korea, clinics administer it both intramuscularly or intravenously for general wellness, immune support, and faster recovery from stress or fatigue. It’s also frequently given as part of “beauty drips” or injected subcutaneously for skin repair and overall rejuvenation.
Users often describe noticeable benefits when they’re run down, recovering from illness, or healing after aesthetic treatments such as microneedling, laser, or thread lifts. Others use it during physical rehabilitation or to stimulate tissue repair in long-term injuries where regeneration has stalled. Its bioactive profile—rich in peptides, growth factors, and nucleic acids—appears to accelerate the body’s natural healing responses, improve energy, and subtly enhance skin tone and texture over time.
Although results vary, Laennec is valued for its broad regenerative potential: it supports the body’s own repair systems rather than targeting a single condition. This “whole-system” benefit is why it has quietly remained a mainstay in Asian anti-aging and recovery protocols for decades, despite limited awareness in the West.
Many DIYers like to use a vial post-microneedling on the face, neck, or chest. Some use it for mesotherapy, or to flush bruises and speed wound healing.
While there are many ways to use it, I personally use it for overall systemic health and when I need to fight illness.
Supplies You Need
I am going to make this easy and provide Amazon links.
- Laennec ampoules – comes in either a 10- or 50-pack from Korean specialty retailers
- Alcohol swabs – to sterilize the injection site
- Glass ampoule opener – either of these will work; I prefer the clip-style one (it’s a bit janky but effective)
https://www.amazon.com/dp/B0CJVJC9PR
https://www.amazon.com/dp/B09C1MWXC7 - 3mL Luer Lock Syringes – large enough to hold the full contents of an ampoule; these are the most common size
https://www.amazon.com/dp/B0BVP3M4WC - Filter needles – the 18G 1.5in (38mm) are ideal to filter out any glass particles from the ampoule
https://www.amazon.com/gp/product/B07D95XVN6 - Injection needles to go on the Luer Lock syringe – you may need something different if you want to inject in a specific area, but if doing systemic wellness in the abdomen I recommend the 27G 13mm (13mm = 1/2 inch). The 27G will go through the thick abdominal skin well and the Laennec flows easily through it. The 13mm length is better for depositing into the right plane as you don’t want it to bubble up just under the skin.
https://www.amazon.com/dp/B08H1QVN5T - Sharps container – for safe disposal of used needles
You can also buy supplies from Anton Move, a China-based supplier that ships globally and offers higher quality, sharper needles at great prices.
How to Do It
When you have everything:
- Break open the ampoule with one of the openers by scoring the neck then snapping it off. Try not to shatter the glass!
- Attach the 18G filter needle to the 3mL syringe
- Draw the contents into the syringe. The filter will make sure no glass enters the syringe
- Trade out the needles: discard the filter needle, replace with the injection tip
- Choose your location and inject slowly
Choosing the Location
For subcutaneous (SubQ) wellness injections — what I do — inject into the abdominal fat. Aim for off-center, not directly over the navel. Pinch up the fat, insert the needle at about 45°, release the pinch, and depress the plunger slowly to allow dispersion.
Mild tingling, itching, or swelling for 15-30 minutes is normal — I get this — and usually subsides quickly; slower injection helps minimize this.
You can also split the dose into two smaller injections (for example, one near an injury and one in the abdomen). The key thing is you cannot save any of the ampoule for later; you need to use it immediately after opening or discard any leftover.
For targeted injury repair you will need intramuscular (IM) injections directly into or near the affected muscle or tendon. This is trickier, you will need to study the anatomy of the area to figure out the specific depth and angle to get there. I cannot help with that, but there are videos and advice out there if you look.
How Often?
It really depends on your situation.
- General wellness: SubQ 1 × per week.
(Optionally 2× weekly if your lifestyle involves more toxins, alcohol, or inflammation.) - During illness or fatigue: SubQ 1 × per day until recovered.
- Injury recovery: If this is a fresh injury I’d say daily until you see progress, then slow it down. If it’s a chronic, old injury that flares up, maybe every few days. I really can’t say, you will have to see what works for you. Just don’t do it more than once per day as overloading the system doesn’t help either.
How Soon Will You See Results?
Everyone is different, so take this as general guidance:
- If you are taking it for wellness you may not notice anything specific. Your body will direct it to where it can use it, which may be to heal your liver; this is one of it’s most studied uses. Would you notice if your liver was healing? Probably not. Once your body’s deeper repair priorities are met, many people notice improvements in skin quality, recovery speed, and overall vitality. But depending how well you live your life — the toxins, the inflammation, etc — you may be keeping that Laennec pretty busy even if you’re unsure and wonder “is it working.” This can be a silent helper.
- If you are taking it for a recent injury you should notice that you heal much quicker. If you had surgery in the area, surgical scars heal faster and appear less visible. Your torn ligaments and tendons may heal, perhaps even regrow and reattach.
- If it is a chronic, old injury you can potentially restimulate healing and repair in the area. This will take much longer, and results vary widely depending on the situation.
Laennec can do amazing things, but it does take time and you may not even notice it. But given it’s long history of use in Japan and South Korea, you can be confident it is doing something.
For me, Laennec has earned permanent status in my cabinet. I recommend it to friends all the time.
Further Reading
- JBP: Laennec product page — overview, composition, safety, and historic clinical data.
- JBP: Laennec P.O. (oral) — shows the broader Laennec family and JBP’s safety language.
Clinical & Mechanistic Papers
- Human placental extract for liver disease (review & mechanisms) — open-access summary of hepatic effects and pathways.
- Efficacy & safety of HPE in steatohepatitis (multicenter clinical trial) — J-STAGE article on ASH/NASH.
- Health status after HPE (includes Laennec citations + hepatectomy data) — open-access review with references to IV vs SC studies.
- Ligament healing (rodent model, PubMed) — suggests tissue-repair potential beyond liver.
Trials & Documents
- Laennec in chronic liver diseases (Phase 3; ClinicalTrials.gov) — current randomized study entry for context.
- Chronic fatigue study (ClinicalTrials.gov) — investigator-initiated trial of Laennec Inj.
- Laennec SmPC-style PDF (product document) — concise summary including classic Japanese studies.
How It’s Used in Japan (English-language clinic explainer)
- Tokyo clinic overview of placenta injections (Laennec & Melsmon; MHLW-approved) — practical framing of local medical use.
Retail
Meamo (use code HDK15 for extra discount, even during sales)
Skin Global – WhatsApp +82 10-2942-7225 to request catalog and order form
This article reflects independent analysis and interpretation based on publicly available information and scientific literature. It is not affiliated with or endorsed by any of the brands or products mentioned.