Which Rh Human Collagen Injection is Best?

The world of aesthetic medicine is shifting from temporary volume “filling” with HA fillers to long term “biostimulation.” Recombinant human-like collagen (RHLC) injectables are at the forefront of this change, offering lab-engineered, non-animal-derived alternatives that are molecularly nearly identical to the collagen in your own body.

Prior to 2021, animal-derived collagens – specifically bovine (cow) and porcine (pig) – were the leading global industry standards for several decades. The market began a structural shift in June 2021 with the first NMPA-approved recombinant humanized collagen injectable. By 2025, this matured into a profusion of specialized South Korean releases, successfully moving the category from ‘human-like’ functional fragments toward 100% human-identical sequences.

Brand Comparison

Brand	Primary Collagen Type(s)	Key Ingredient Amounts	Unique Features & Synergistic Components	Manufacturer
PuriColl Rh	Recombinant Type I & Type III	15 mg Total RH Collagen (7.5 mg Type I + 7.5 mg Type III); 50 mg Hyaluronic Acid; 5 mg PDRN	Features Succinic acid and PDRN to enhance DNA-level tissue repair. Includes multi-peptides (e.g., Galloyl Tripeptide-35) to prevent collagen degradation.	Wederm/ Aeterderm
Lapiena RH-X	Recombinant Type I & Type III	15 mg Total RH Collagen (7.5 mg Type I + 7.5 mg Type III); 50 mg Hyaluronic Acid	Dual-type formula that integrates Exosomes, Succinic Acid, and Niacinamide to accelerate skin recovery and restore firmness.	HJ Corp
Hulaboo	Recombinant Type I	10 mg RH Collagen; 50 mg Hyaluronic Acid	Most minimalist formula, strictly collagen and HA with no secondary benefits.	Quiver Medic
Skincolla	Recombinant Type I	10 mg RH Collagen; 50 mg Hyaluronic Acid	Utilizes a 100% human-identical gene sequence matching GenBank to promote natural skin regeneration and elasticity.	Maypharm
Karisma	Recombinant Type I (α1 chain)	200 µg/mL RH Collagen (approx. 0.4 mg per 2 mL syringe); 200 mg/mL Hyaluronic Acid	Produced using transgenic silkworm technology. Contains Carboxymethyl Cellulose (CMC) to protect natural hyaluronic acid through antioxidant action.	Taumedika Srl (Italy)
Tesoro Collagen	Recombinant Human-Like (RHLC)	Amount not specified by manufacturer; Hyaluronic Acid included	Tesoro does not publicly disclose the specific milligram amount of collagen per syringe. It emphasizes a blend of amino acids and Tripeptide-1.	BNC Global

Key Product Highlights

1. The High-Potency Duo: PuriColl Rh & Lapiena RH-X

These brands lead the category in concentration transparency, offering a combined 15 mg of dual-type collagen. They are similar in the main ingredients, but differ in the secondary ingredients:

PuriColl Rh: designed for intensive tissue repair and stability. It uses PDRN and succinic acid to recharge fibroblasts and specific multi-peptides to actively inhibit the enzymes that break down existing collagen.
Lapiena RH-X: a more comprehensive skin quality and recovery booster. While it also uses succinic acid to stimulate fibroblasts, it adds exosomes to amplify cellular messages for regeneration. Its inclusion of Glutathione and Tranexamic Acid makes it more suitable for those also concerned with hyperpigmentation and uneven skin tone.

2. The Italian Innovation: Karisma

Produced in Italy, Karisma uses unique technology involving transgenic silkworms to produce human-identical Type I collagen α1 chains. Clinical studies show it significantly reduces skin roughness and improves quality without age-related correlation. It also includes Carboxymethyl cellulose (CMC), which acts as an antioxidant to protect the skin’s natural hyaluronic acid.

3. The Minimalist Standards: Hulaboo & Skincolla

Both brands offer a straightforward 10 mg of Type I RH collagen. These are ideal for those seeking pure collagen stimulation without additional bio-active reparative ingredients like exosomes or PDRN.

4. The Transparency Outlier: Tesoro

While Tesoro is heavily promoted by influencers and featured on global distribution platforms, it remains the primary brand that does not disclose its exact milligram concentration of collagen. It markets a “bioidentical” peptide-rich formula, but the lack of raw data makes direct potency comparisons difficult.

Personally, I avoid products that do not disclose important information, all while employing a lot of marketers to promote it all over social media. In this case, there are clearly better brands available.

Why Type I & Type III Together?

Newer formulations often combine both types rather than just offering high amounts of Type I.

Type I (Firmness): The “steel beams” of the skin, providing density and structural foundation.
Type III (Suppleness): Known as “baby collagen,” it provides the elastic bounce and flexible scaffolding necessary for a youthful, dewy texture.

What Are The Benefits?

Injecting recombinant human-like collagen (RHLC) provides a dual-action approach: it offers immediate structural support while triggering a biological signal for your skin to rebuild itself from within.

1. Key Benefits of RHLC Injections

Unlike traditional fillers that simply take up space, RHLC acts as a biostimulator.

Dermal Density: Restores the skin’s thickness and “bounce” by replenishing the extracellular matrix.
Youthful Suppleness: High-quality Type III collagen improves elasticity and softness, effectively reversing “crepey” texture.
Cellular Signaling: Acts as a scaffold that encourages your fibroblasts to produce native collagen and elastin.
Minimal Inflammation: Because it is molecularly identical to natural human collagen proteins, it carries a significantly lower risk of the nodules or allergic reactions common with animal-derived versions.

2. Timeline for Results

Results occur in phases as your body responds to the “controlled injury” of the injection.

Week 1: You may notice an “instant glow” and improved hydration due to the synergistic hyaluronic acid (HA) found in many RHLC boosters.
Weeks 4–8: This is the Building Phase. You will start to see subtle improvements in skin quality, tone, and texture as new collagen fibers begin to form.
Months 3–6: This is the Refinement Phase, where maximum benefits typically appear. Facial contours look more defined, and fine lines are visibly reduced.

3. Typical Treatment Protocol

While your specific product will have a plan, the standard industry protocol for most RHLC boosters includes:

Initial Series: 3 sessions spaced approximately 2 to 4 weeks apart to “bank” enough collagen to see a significant shift.
Maintenance: One “top-up” session every 6 to 9 months to maintain the collagen network and combat natural age-related degradation.

Who Should Consider Recombinant Human-like Collagen Treatments?

The ideal profile for an RHLC candidate includes:

1. The “Prejuvenation” Demographic (Ages 25–40)

Goal: To “bank” collagen before significant loss occurs.
Benefit: Because Type III collagen is the first to decline as we age, starting RHLC early helps maintain that youthful “baby collagen” ratio, delaying the onset of static wrinkles and sagging.

2. The “Crepey Skin” and Fine Line Candidate

Goal: Improving texture rather than adding volume.
Benefit: People with thin, translucent, or “crepey” skin (often on the neck, décolletage, or under-eyes) benefit most. RHLC thickens the dermis and restores suppleness without the risk of the “Tyndall effect” (blue tint) or lumpiness often seen with HA fillers in thin-skinned areas.

3. The “Sensitive” or “Reactive” Individual

Goal: Anti-aging results without the risk of immune reactions.
Benefit: For individuals who have had adverse reactions to animal-derived products, or those with sensitive systems wary of synthetic cross-linking agents (like BDDE found in many HA fillers), the non-immunogenic nature of RHLC is a major advantage.

4. Post-Procedure Recovery Candidates

Benefit: Since products like PuriColl Rh and Lapiena RH-X include PDRN or Exosomes, they are ideal for people recovering from laser resurfacing or microneedling. The collagen acts as a scaffold, while the boosters accelerate tissue repair.
Goal: Speeding up healing and maximizing results of other treatments.

Brand Comparison

Key Product Highlights

Why Type I & Type III Together?

What Are The Benefits?

Who Should Consider Recombinant Human-like Collagen Treatments?

Further Reading