Dermagen EXOSIA vs
ExoHealer Filcore P198 SB

Comparison: Dermagen EXOSIA vs ExoHealer P198 Filcore SB

by SK | Beauty Jumpstart | November 2025

When it comes to true regeneration - not just hydration or brightening - three exosome skin boosters stand at the top of the field: Dermagen Plus EXOSIA, ExoHealer P198 Filcore SB, and ExoHealer P198 Filcore SB Plus. Each represents a top-tier Korean biotech formulation focused on true regeneration and cellular renewal, offering options that range from microneedling-friendly recovery to full clinical-depth rejuvenation.

All three are powered by the same human umbilical-cord-derived exosomes from Cell Bio Science’s USC1994-CMT platform, one of Korea’s leading GMP-certified biotech labs. The exosome material itself is identical in lineage and purity across all three; what differs is the concentration and the activating solution that delivers it. EXOSIA and P198 SB each contain roughly the same exosome load (49.2 billion particles), while P198 SB Plus is a highly concentrated version that's about five times stronger (245.7 billion particles).

The P198 Filcore formulations also include the proprietary USC1994-SPC peptide complex with the exosomes, which enhances collagen signaling and dermal repair, making them ideal for deeper mesotherapy or BAP protocols where regenerative intensity matters most. Dermagen EXOSIA, by contrast, pairs the same exosome platform with a soothing, peptide-rich cosmetic activator optimized for post-laser or microneedling recovery. In practice, EXOSIA is the go-to choice for cosmetic-depth rejuvenation and surface healing, while P198 Filcore SB and SB Plus are built for injection-depth regeneration and true clinical-grade repair.

Bottom line

• EXOSIA Solution → “Comfort + Glow.” Best for cosmetic microneedling, barrier repair, and hydration.

• P198 Solution → “Clinical + Rebuild.” Best for meso/BAP sessions requiring a deeper-penetrating clinical carrier .

Both share the same high-purity Cell Bio exosome lineage; what changes is the delivery style.  

How Do We Know the Intended Depths? Formulation clues

EXOSIA Activator

• Contains Niacinamide and cosmetic peptides (Palmitoyl Tetrapeptide-7, Acetyl Hexapeptide-8),  ingredients designed for topical barrier repair and cosmetic microneedling, not intradermal use.

• Uses a thicker, cushiony HA-based texture, ideal for glide and comfort during cosmetic MN.

• Uses a topical-style preservative system (phenoxyethanol + ethylhexylglycerin), further indicating surface-level application.

P198 Filcore Activator

• Formula contains no cosmetic peptides or botanical extracts. Instead it uses a clinical mesotherapy-style base:
  Water + Sodium Chloride + Sodium Hyaluronate + 22 amino acids + 13 vitamins + minerals/electrolytes.

• This combination mirrors a physiologic, injectable-friendly carrier, designed to disperse easily in dermal tissue.

These compositional differences strongly suggest intended delivery depth even if not directly stated.

Regulatory and packaging cues

• The EXOSIA line is registered in Korea under the cosmetic category.

• The P198 Filcore series is listed as  “병의원용 화장품” or “병의원전용”  which translates to "clinic-use cosmetic / hospital-exclusive product".

That distinction dictates whether clinics can legally inject it or only apply topically.
So while both are “activators,” their formulation architecture and distribution pathway reveal their use cases rather than a line printed on the label.

Further Reading

ExoHealer P198 Filcore SB Plus - Product Brochure PDF 

https://exosia.co.kr/

https://maxcore.co.kr/shop_view/?idx=283

This article reflects independent analysis and interpretation based on publicly available information and scientific literature. It is not affiliated with or endorsed by any of the brands or products mentioned.